ENDRA began with the first—and only—commercially available fully 3D photo-acoustic imaging system: Nexus 128. The technology, now evolved to Nexus 128+, allows researchers to better visualize and represent anatomy, physiology and labeled molecular targets.
Fully 3D imaging provides increased sensitivity, isotropic resolution, improved image quality, faster scan times and higher throughput.
|Nexus 128 3D Systems||Slice-Based 2D Systems||Impact|
|True 3D imaging||
3D detector and 3D reconstruction algorithm yield full volumetric images of target tissue with every laser pulse.
|4D scanning (volume + time)||
4D scans enable analysis of multiple volumes of interest simultaneously without compromised image quality.
|3 second dynamic mode||
Full volumetric (3D) dynamic scanning speeds as low as 3 seconds without compromised image quality.
|Isotropic image volumes||
3D reconstruction with resolution equal in all directions is unaffected by animal positioning.
|Ability to image broad range of fluorescent molecular probes||
Ability to image tail vein injected NIR molecular probes, e.g., Alexa Fluor® 680 & 700 and CyTM5.5.
Mutliple wavelength scans (680-950nm) enable tissue differentiation based on optical absorption.
|Molecular probe uptake and distribution||
Ability to locate and quantify targeted molecular probes.
|Image endogenous and/or exogenous probes||
Generate images of vasculature without contrast agent or vasculature and probe when NIR probe is injected.