A new perspective for lab research

ENDRA began with the first—and only—commercially available fully 3D photo-acoustic imaging system: Nexus 128. The technology, now evolved to Nexus 128+, allows researchers to better visualize and represent anatomy, physiology and labeled molecular targets.

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Photo-acoustic enhanced ultrasound: Nexus 128+

Fully 3D imaging provides increased sensitivity, isotropic resolution, improved image quality, faster scan times and higher throughput.

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See Nexus 128+ in action

How it works

Tomographic images of optical absorption are generated using endogenous and/or exogenous contrast. Photo-acoustic CT is suitable for contrast-enhanced and molecular imaging applications through the use of near-infrared absorbing dyes or fluorescent probes.

Key applications

Molecular probe uptake and distribution

Molecular probe uptake and distribution

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Tumor vasculature—hemoglobin concentration

Tumor vasculature—hemoglobin concentration

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Tumor hypoxia—SO2

Tumor hypoxia—SO2

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Spectral analyses

Spectral analyses

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The benefits of a fully 3d imaging system

Nexus 128 3D Systems Slice-Based 2D Systems Impact
True 3D imaging

3D detector and 3D reconstruction algorithm yield full volumetric images of target tissue with every laser pulse.

4D scanning (volume + time)

4D scans enable analysis of multiple volumes of interest simultaneously without compromised image quality.

3 second dynamic mode

Full volumetric (3D) dynamic scanning speeds as low as 3 seconds without compromised image quality.

Isotropic image volumes

3D reconstruction with resolution equal in all directions is unaffected by animal positioning.

Ability to image broad range of fluorescent molecular probes

Ability to image tail vein injected NIR molecular probes, e.g., Alexa Fluor® 680 & 700 and CyTM5.5.

Multispectral imaging

Mutliple wavelength scans (680-950nm) enable tissue differentiation based on optical absorption.

Molecular probe uptake and distribution

Ability to locate and quantify targeted molecular probes.

Image endogenous and/or exogenous probes

Generate images of vasculature without contrast agent or vasculature and probe when NIR probe is injected.