Lab

More information,
more efficiently

With fully 3D photo-acoustic imaging, Nexus 128+ delivers a whole new spectrum of information—more quickly and easily—to researchers studying anatomy, physiology and labeled molecular targets.

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Key applications

Molecular probe uptake and distribution

Molecular probe uptake and distribution

Tumor vasculature—hemoglobin concentration

Tumor vasculature—hemoglobin concentration

Tumor hypoxia—SO2

Tumor hypoxia—SO2

Spectral analyses

Spectral analyses


Key features

Fast, dynamic imaging

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Fast, dynamic imaging

Video depicts the uptake of Indocyanine Green (ICG) in the vasculature of a subcutaneous PC3 tumor and surrounding tissue over a 3 minute period. Full, 3D volumes (25x25x25mm) were acquired every 3.5 seconds.

Predefined tumor biology and probe uptake protocols

Easy-to-use graphical interface

Multi-spectral imaging

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Multi-spectral imaging

A tunable laser (680-950nm) and high sensitivity allows users to perform spectral analyses of novel probes and contrast agents ex vivo or in vivo. The video below (below) shows a multi-wavelength display of a subcutaneous tumor following injection of a NIR tumor-targeting probe in vivo. Images were acquired at seven different NIR wavelengths (12sec per scan) and displayed in OsiriX image viewing and analysis software.

Flexible “research mode” for advanced scan parameters

Compact, easy-to-site system

Simple, efficient animal handling

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Simple, efficient animal handling

Animals may be placed in any orientation in the animal tray which is locked into place above the detector array. A small amount of water (>20ml) placed between the animal and the bottom of the tray provides a uniform interface between the tissue and the US transducers without submersion. A small port in the lid allows passage of anesthesia hoses and catheters.

Advanced reconstruction algorithms

Powerful viewing and analysis software

A closer look

Nexus 128+ offers a variety of features to help researchers see and accomplish more. Here are a few features that make it a powerful tool in the lab.

Simple, efficient animal handling

Animals may be placed in any orientation in the animal tray which is locked into place above the detector array. A small amount of water (<20ml) placed between the animal and the bottom of the tray provides a uniform interface between the tissue and the US transducers without submersion. A small port in the lid allows passage of anesthesia hoses and catheters.

Easy-to-use graphical interface

The graphical user interface (GUI) is easy to use and guides the operator through system startup, database management, scan acquisition, volume reconstruction and transfer of the data to the analysis workstation.

Integrated interactive database

The integrated database keeps the data organized and is easily sorted by user, study, specimen and exam. The database is particularly useful for multi-user centers and longitudinal studies.

Data Visualization and Analysis

The 3D photo-acoustic data are transferred from the Nexus 128+ to a workstation for viewing and analysis.

Data on the workstation have the same structure/organization as the Nexus 128+ scanner.

Separate workstation allows an investigator to analyze data while another operator is acquiring data.

OsiriX viewer has powerful built-in tools.

ENDRA provides OsiriX plugins for application-specific quantitation.

See how the Nexus 128+ system aids researchers in the lab.

These institutions use Nexus 128 and nexus 128+.